Here is a selection of photos before, during, and after the historic match.
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Emotions were on display as thousands of fans turned up to Wembley to show their support.
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There was a festive atmosphere outside stadium.
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This fan used the occasion to show off his England tattoos.
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Thousands of supporters cheered and chanted in the build-up to the match.
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Hopes were high as fans gathered around the country to watch the game.
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The Red Arrows performed a flyover above Wembley Stadium in support of the England team.
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A large replica of The Henri Delaunay Trophy is seen while performers dance inside the stadium prior to kick-off.
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This was English football's most important day for more than half a century and the team was urged on by a fervent crowd.
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England were up and running with an early goal from Luke Shaw after two minutes.
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Fans in Manchester had barely settled into their seats before the opportunity for celebration.
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Wembley grew anxious as Italy gained possession. Experience proved critical for the Azzurri (Blues).
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Italy dominated possession and Leonardo Bonucci restored parity from close range in the 67th minute.
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Italy's goal dampened the party atmosphere at the fan zone in Trafford Park, Manchester.
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It was a very tough second half for England, with Italy in control. As extra time loomed, Giorgio Chiellini fouled Bukayo Saka.
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A tense period of extra time failed to find a winner, it was on to penalties.
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The Duchess of Cambridge appeared unable to watch.
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Under Gareth Southgate, the young side provided the nation with hope.
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England missed three of their five penalties, Marcus Rashford hitting a post and Gianluigi Donnarumma denying Jadon Sancho.
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Italian fans at home in Rome were tense as Jordan Pickford kept England hopes alive with saves from Andrea Belotti and Jorginho.
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Arsenal teenager Bukayo Saka saw the giant Italy goalkeeper save his spot-kick.
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The tearful 19-year-old Saka, who showed such courage to step forward, was consoled by his team-mates and manager.
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The moment in Manchester when it became clear the dream was finally over
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In the end, it was spot-kick suffering for England once again as jubilant Italian squad rushed towards their keeper to celebrate victory.
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Italy fans cheered in Piccadilly Circus in central London as their team won.
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There were triumphant scenes across Italy. Here supporters celebrate in Piazza del Duomo in Milan.
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Ecstatic fans started street parties across the country immediately.
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England fans at the Trafalgar Square Fan Zone in London were dejected after the loss.
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The result was a familiar tale of disappointment.
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Italy edged over the line and both Southgate and his players looked devastated, as were the fans at Wembley.
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England's years of hurt go on. Dreams of a major trophy shattered once more.
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Italy's players and staff celebrated in front of their exultant fans. Euro 2020 was their sixth major tournament title, only Germany (seven) have won more.
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As despondent fans made their way home, a huge clean-up operation began.
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