30 October 2025

31 minutes

Available for over a year

Chris and Xand continue their conversation with Dr James Rucker, a consultant psychiatrist at King's College London who is leading the European arm of a global trial of a psychedelic designed to treat people with severe depression.

They discuss the history of psychedelics, the discovery of LSD and the popular (and often illegal) practice of microdosing. Is there any evidence to suggest that taking minute quantities of psychedelic substances will boost your brain function or mood?

Chris and Xand also discuss their own experience of taking psychedelics several years ago for a TV series about traditional medicines.

If you’d like to share your thoughts on this or any other topic covered on the podcast, you email us at [email protected] or Whatsapp on 08000 665 123.

Presenters: Drs Chris and Xand van Tulleken

Guest: Professor Andy Smith

Producer: Jo Rowntree

Executive Producer: Rami Tzabar

Editor: Kirsten Lass

Assistant Producer: Maia Miller-Lewis

Assistant Producer and Researcher: Emily Bird

Tech Lead: Reuben Huxtable

Social Media: Leon Gower

Digital Lead: Richard Berry

Composer: Phoebe McFarlane

Sound Design: Melvin Rickarby

At the BBC:

Assistant Commissioner: Greg Smith

Commissioning Editor: Rhian Roberts

A Loftus Media production for BBC Radio 4.