League Two's bottom side Luton Town have been drawn at home to Colchester in the southern area semi-finals of the Johnstone's Paint Trophy.
Shrewsbury, fifth in League Two, face Brighton, who beat Swindon in a delayed quarter-final.
In the northern section, League Two leaders Darlington take on struggling Rotherham while Scunthorpe, top of League One, will face Tranmere.
All four ties will be played the week commencing 15 December.
Northern Section
Scunthorpe v Tranmere
Rotherham v Darlington
Southern Section
Luton v Colchester
Shrewsbury v Brighton
Ties to be played week commencing 15 December
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