Focus
Focus means how much of the image is sharp. This can be used to emphasise a cetain point. For example, if someone stands with their arm out in front of them, you could focus on their hand or their face. This can create meaning in an image.
A Bitesize video guide to using autofocus and manual focus.
Depth of field
Depth of field means how much of the image is in focus. You can have a narrow depth of field, where only a small part of the image is in focus, or you can have a larger depth of field, where everything is in focus. Depth of field is controlled by the aperture. A larger aperture means a narrower depth of field.
A Bitesize video guide to depth of field.