The Kassam Stadium has staged international junior matches previously
The Kassam Stadium has been named as the venue for the International Challenge Trophy final in May.
The match will be between England C and their Belgian counterparts.
Oxford striker James Constable's late goal in the 2-2 draw in Italy last year sealed qualification for the non-league representative side.
The news comes as the Stadium Company - owned by Firoz Kassam - has agreed a profit-sharing deal with Oxford United over ground advertising.
The deal also includes matchday catering and conferences booked through the football club.
United chairman Kelvin Thomas said: "One of my focuses when I first came in as chairman was to develop the relationship between the club and Firoka [Kassam's company].
"Firoz has been excellent and he recognises the position the club found itself in, and he has worked with us to help us through our short-term issues."
Kassam, who sold the football club in 2006, said: "We see this as a real positive move for the company. I have been happy to help the club over the last few months and feel by entering into this agreement it will develop our relationship so the club can see some more commercial benefit.
"We have worked hard on developing this and also discussing other ways we can work together. Both companies now have strong commercial teams which when working together should be able to maximise the revenue."
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