Lewes have the chance to move out of the Blue Square South bottom three with victory at Eastleigh on Saturday.
In the Ryman Premier League, Hastings United will look to extend their unbeaten run to four matches against AFC Hornchurch at the Pilot Field.
Horsham welcome Waltham Abbey to Gorings Mead, while Bognor can move out of the bottom four with victory at fellow strugglers Cray Wanderers.
Division One leaders Worthing welcome Whyteleafe to Woodside Road, Horsham YMCA go to Leatherhead, Burgess Hill make the trip up the A23 to play Merstham and Eastbourne Town visit Walton & Hersham.
Seven Sussex sides have made it through to the second round of the FA Vase, with the draw producing two all-County League ties.
Arundel meet Crowborough Athletic and will be out to avenge their league defeat at Mill Lane back in September.
The visitors are rock bottom of the County League table and have conceded 21 goals in their last four outings.
Redhill were well beaten by Shoreham in the league last month, but have home advantage for Saturday's tie.
Whitehawk, who reached the quarter-finals three years ago, meet Wessex League outfit Fareham at East Brighton Park.
Eastbourne United Association, quarter-finalists in 1979, also take on Wessex League opposition, with Hamble ASSC the visitors to the Oval.
In the other tie, Peacehaven & Telscombe make the trip to Buckinghamshire to play Chalfont St Peter, beaten on penalties by Glossop in last season's semi-final.
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