Plymouth Parkway kick off the weekend's action in the South West Premier League at home to local rivals Saltash United on Friday evening.
On Saturday, last season's champions Bodmin Town face an away trip to Witheridge, who have have won all three of their opening fixtures.
Elburton Villa travel to Cullompton Rangers, whilst Ivybridge make the trip to Falmouth Town.
Wadebridge host Clyst Rovers, with both sides yet to win in the league.
Dartmouth are at home to Bovey Tracey, whilst Launceston will looking for their first win of the season when they host St Blazey.
Buckland Athletic make the trip west to Penzance, whilst Tavistock meet Holsworthy at home.
The weekend's final fixture sees Torpoint meet local rivals Liskeard Athletic.
SWPL Fixtures - Friday, 21 August
Plymouth Parkway v Saltash United
Saturday, 22 August
Launceston v St Blazey
Wadebridge v Clyst Rovers
Dartmouth v Bovey Tracey
Falmouth Town v Ivybridge Town
Witheridge v Bodmin Town
Penzance v Buckland Athletic
Cullompton Rangers v Elburton Villa
Tavistock v Holsworthy
Torpoint Athletic v Liskeard Athletic
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