Jason Smyth has a 100m personal best of 10.61

Smyth, who broke his own world record in the 200m on Monday, was ahead of German Matthias Schroeder (11.05) and South Africa's Jonathon Ntutu (11.25).

Belfast athlete Michael McKillop safely qualified for Friday's T37 800m final.

McKillop, who won 1500m silver on Sunday, finished second in Wednesday's semi-final in a time of 2:13.56.

Smyth said he had been "confident all week despite a couple of injury worries".

"It has been a great series of races for me and I have learnt a lot about championship running this week," said the Eglinton man.

Andre Andrade of Brazil, one of the main rivals to Smyth, was disqualified for false starting but the Irish athlete maintained his concentration to become the first Irish Paralympian to become a double world athletics champion.

Smyth also competes in able-bodied competitions and he equalled the Irish junior record of 10.61 earlier this year.

My target was a podium place and my world record is still intact Lisa Callaghan

Lisa Callaghan then went on to claim Ireland's fifth medal of the week when she took silver in the F37 javelin event.

Callaghan's first round throw in the competition reached 22.75 and left her behind Tunisia's Ayda Sidhom (24.02).

"I am happy to come away with a medal because the competition was tight and I could have ended up with nothing," said Callaghan.

"My target was a podium place and my world record is still intact, so I'm pleased with that."

Roy Guerin progressed from the semi final of the T54 100m.

The Kerry wheelchair athlete recorded a time of 16.33 seconds and he will be the only European in Thursday's final.

The IPC World Championships is the most prestigious event for disability athletes outside the Paralympic Games, with 1500 athletes competing from 77 countries in 240 events.

The Irish team comprises of 14 Athletes (10 Men, 4 Women) from three disability groups, supported by a staff complement of 9 coaches and officials.