Eddie Jones has made four changes to his Australia side, picking what he considers to be his best 22 for Saturday's Twickenham clash against England.

Hooker Jeremy Paul, prop Bill Young and locks Dan Vickerman and Justin Harrison all return after the 18-9 defeat against Ireland in Dublin last weekend.

Behind the scrum, Queensland's Elton Flatley wins a spot at centre, so Stirling Mortlock moves to the wing and Scott Staniforth is dropped.

Skipper George Gregan leads Australia despite his 20,000-mile round-trip back home earlier this week to attend the birth of his second child.

"It is a very flexible side, and we are talking about the whole 22 here, so I would expect the players to play in different positions during the game," said Jones.

"This is our best 22 after taking into account injuries and form in the matches against Argentina and Ireland."

Paul returns to the starting line-up after missing the Ireland game because of hamstring strain.

Jones was forced into making one second-row switch because of an injury to Owen Finegan, but has gone the whole hog and called up Vickerman and Harrison, while loosehead prop Bill Young replaces Nick Stiles.

Jones said in October that he aimed to use the Wallabies' Tests as Argentina and Ireland to fine tune the squad, with his full first-choice team being picked for the Twickenham encounter.