Their opponents in Carcassonne on 5 November will be France, who crushed Georgia 60-0 in Tbilisi on Sunday.
Wales led 19-0 at the interval thanks to tries from Anthony Blackwood, Richard Johnston and Adam Hughes.
Blackwood got his second after the break before a penalty try completed the win. Ireland's tries came from Michael Platt and Francis Cummins.
Ireland coach Daryl Powell:
"Wales out played us and took their chances, and you have to give them credit for that. "We are still fairly positive about building a successful squad for the World Cup.
"In this campaign we blooded eight new players from the amateur game in Ireland, each of those guys have huge potential for the future and they have shown they are well able to hold their own in the professional arena."
Ireland: Cummins, Platt, Stewart, Littler, Gaskill, Fitzpatrick, Handforth, O'Connor, Gambles, McDermott, McNicholas, Corcoran, Finnegan.
Replacements: Haggerty, Brodie, O'Riordan, Treacy.
Wales: Gibson, Powell, Blackwood, Hughes, Johnston, Briers, Lennon, Mills, Watson, Dean, Morley, James, Joseph.
Replacements: Morgan, Woodard, Smyth, Price.