Chris Bridge's five tries were more than he had in Super League all season
Holders Warrington cruised into the last eight of the Challenge Cup with an astonishingly one-sided victory over last year's beaten finalists.
England centre Chris Bridge ran in five tries for the Wolves as the repeat of the 2009 final turned into a mismatch.
The visitors killed the contest with five tries in 20 first-half minutes.
And it remained one-way traffic, Chris Hicks' hat-trick and tries from Ryan Atkins, Richie Myler, Chris Hicks and sub Mickey Higham completing the rout.
Having been rocked by that five-try surge after making a bright start, Huddersfield only briefly recovered their composure, when they scored their only try straight after the restart through substitute Martin Aspinwall.
But this was in-form Warrington's day again as, fresh from Sunday's 68-16 Super League win over Salford at Murrayfield, they ran in 12 tries for the second weekend running.
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Centre Bridge, who began his professional career at Huddersfield, and his Australian winger Hicks led the way, eight of their side's dozen tries coming down the right.
And, although the Giants were poor, it was a ruthless attacking display which soon ended any hopes Huddersfield might have had of avenging last August's 25-16 Wembley defeat.
After an unsettled couple of weeks, following confirmation of captain Brett Hodgson's impending move to Warrington amid rumours that coach Nathan Brown will quit at the end of the season, it did little to lift the gloom over the Galpharm Stadium.
Hodgson returned to the Giants line-up, a fortnight ahead of schedule after being sidelined with a calf injury, but he produced an unusually slipshod performance which characterised his side's overall display.
In contrast, Richard Mathers - the man set to make way for Hodgson's arrival at the Halliwell Jones - was among a host of impressive performers for the Wolves.
And, once centre Atkins had opened the scoring on 14 minutes it was a steady procession over the Huddersfield line.
Bridge pounced for his first try after David Hodgson slipped, deceived by a wicked bounce from Lee Briers' kick.
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Bridge then went between the winger and Paul Whatuira for his second before carving out a try for Myler, while Hicks went over for his first after Mathers' pass found him unmarked.
Aspinwall pull one back three minutes into the second half but Huddersfield's handling errors continued.
Hodgson spilled Cudjoe's pass five metres from his own line, Briers reacting quickly to get Bridge over for his hat-trick.
Briers then released the centre on halfway for try number four and his fifth came courtesy of a pinpoint kick from Myler.
The pressure from the visitors was unrelenting and substitute winger Riley went over unopposed at the corner, before Hicks went over twice in seven minutes to complete his own treble and Matt King broke clear to get hooker Higham over.
Warrington coach Tony Smith told BBC Sport:
"Things fell for us today. One of those days when everything comes off.
"I feel for my opposing coach as I'm a good friend of his and they're a better side than that.
"We've all been there and had a share of that at different times and today was our day.
"We caught them on the hop but the players earned that."
Huddersfield: B Hodgson, Cudjoe, Lolesi, Whaturia, D Hodgson, Brown, Brough, D Griffin, Robinson, Mason, Gilmour, Raleigh, Faiumu. Replacements: Crabtree, Aspinwall, Grix, Horne.
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