But Tom Butler could return to Swansea boss Roberto Martinez's first-team line-up following his recovery from a hamstring problem.
Midfield pair Andrea Orlandi (thigh) and Joe Allen (ankle) will miss out, while defender Marcos Painter remains a long-term absentee with a knee injury.
De Vries has been sidelined since 21 October, when he suffered a hairline jaw and depressed cheekbone fractures following a challenge from Queens Park Rangers captain Martin Rowlands.
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