Southgate was still playing for Middlesbrough in 2006 when a rampant Arsenal thumped a similarly inexperienced Boro side 7-0 at Highbury.
And even though the former England international missed that particular defeat through injury, Southgate is determined to ensure the young players on duty on Saturday are able to learn positively from the defeat.
"It's a horrible experience for everybody, but for any of us who think we've made it as players then there's the harshest lesson possible," he said.
"That's what you have to aspire to to be the very best and sometimes humbling experiences stay with players.
"They get a reality check of how much hard work lies ahead for us."
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