Histon boss Steve Fallon will make changes to his side following Saturday's defeat at Woking.
The Stutes have enjoyed a good start to the season, but have struggled in front of goal in their last two matches.
Fallon told BBC Radio Cambridgeshire: "Maybe it's time for one or two people to be rested.
"Nathanial Knight-Percival looks like he needs a rest so Jamie Barker's going to get his chance, and maybe it's time for Craig Pope to come back in."
Histon also hope to be able to welcome striker Danny Wright back from injury in time for next Saturday's match with Salisbury.
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