The ex-Northern Ireland centre-back needed an escort from the ground as some Glentoran fans vented their fury after that defeat.
He did not attend the Co-operative Cup game against Glenavon three days later on medical advice before informing Glentoran officials of his decision to stay on.
However, Glentoran's league form has remained woefully inconsistent over the last four months in spite of some good results in the cup competitions.
With hopes of retaining the league title now effectively gone, McDonald has come to the conclusion that he can do no more with the team.
However, the timing of McDonald's decision could hardly be much worse for the Glens outfit.
They face Linfield in the JJB Sports Irish Cup quarter-finals next weekend and also have the Co-operative Cup decider against Coleraine to come on 27 March.
McDonald was appointed as Glentoran boss in June 2007 after Roy Walker's one-week reign was cut short because he didn't have the required Uefa licence.
The new manager guided the Glens to the County Antrim Shield in his first year in charge.
Last year, McDonald's Glens clinched the league title as well as guiding the team to a narrow Setanta Cup final defeat by Cork City.
However even in the moments after last season's league triumph, the manager spoke of doubts whether he would remain in charge.
In the event, he did agree a new two-year deal later in the summer but last summer's success now seems a long time ago.
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