Salisbury produced a fine performance to seal an easy win at 10-man Weymouth.
The visitors took the lead when Chris Todd converted Matthew Tubbs' corner and the hosts' Stephen Reed saw red for a professional foul on Luke Ruddick.
Salisbury striker Charles Ademeno was then stretchered off but Tubbs again scored from a corner to make it 2-0.
Charlie Griffin added a third when he sent a right-footed shot beyond Simon Evans before Darrell Clarke completed the rout from close range soon after.
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