Michael Lumb has hit 1,118 one-day runs for Hampshire this summer
Sean Ervine and Imran Tahir each took three wickets as bottom side Notts crumbled to yet another Pro40 Division One defeat at The Rose Bowl.
Hampshire eased to 281-6 from their 40 overs, Jimmy Adams (73), Michael Lumb (61) and James Vince (55) all hitting half-centuries.
But the visitors collapsed to 139 all out to lose by 142 runs.
Notts have just one game left to redeem a Pro40 season in which their only two points have come from wash-outs.
Inexperienced Nottinghamshire were without 10 players. And captain Chris Read had little firepower at his disposal to cope with rampant Hampshire, who finish mid-table on eight points.
Openers Lumb and Adams put on 100 for the first wicket in just 14 overs.
And the carnage continued after Lumb was stumped off Kevin O'Brien for 61, who closed his summer's haul of one-day runs on 1,118 from 29 innings - almost double his efforts in County Championship cricket.
Adams was then joined by Vince in another big stand, this time 98 for the second wicket.
The introduction of Akhil Patel, younger brother of Samit, produced a temporary break in the scoring when Vince (55) swept his first delivery to square leg where Andrew Carter held the catch.
But Adams went on to top score with 73 off 83 balls before he was caught on the midwicket boundary attempting his 10th four.
Notts never looked like reaching their target after losing Mark Wagh to Danny Briggs in the fourth over and Matt Wood to Hamza Riazuddin in the seventh.
Ervine then dismissed Alex Hales with his second delivery and then removed Read and Fletcher, both bowled on his way to figures of 3-23.
And leg-spinner Tahir helped mop up the tail, disposing of Carter and O'Brien in quick succession to finish with 3-30.
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