Manchester City will face Real Madrid for the 16th time in the UEFA Champions League (W5 D5 L5), twice as often as they have faced any other team in the competition (Bayern Munich - 8). This will be the first time two teams have met in the knockout phase of the competition in five consecutive seasons.

Only Bayern Munich (8) and Juventus (7) have won more UEFA Champions League games against Real Madrid than Manchester City (5), who beat them 2-1 in this season's league phase.

Manchester City have been eliminated from the UEFA Champions League by Real Madrid on four occasions, the only side to knock them out more than twice. That includes in each of the last two seasons: 2023-24 quarter-finals and 2024-25 play-offs.

The last away team to keep a clean sheet in a UEFA Champions League knockout stage game away to Real Madrid was Barcelona in April 2011, who were then managed by current Man City boss Pep Guardiola (2-0 win). Since then, the Spanish side have scored in 39 in a row, averaging 2.2 goals per match (86 in total).

Manchester City boss Pep Guardiola will take charge of his 190th UEFA Champions League match here, equalling Alex Ferguson’s total in the competition (190). Following this fixture, Guardiola will only trail Carlo Ancelotti (218) on the list of most Champions League games by managers.

Coming into the round of 16 ties, Manchester City have scored the most goals following build-up sequences (6) in the UEFA Champions League this season, while no side have netted more following direct attacks than Real Madrid (4 – level with Benfica). Los Blancos are also ranked first for total direct attacks (31) this term.

Real Madrid’s Kylian Mbappé has scored more UEFA Champions League goals against Manchester City than any other opponent (7), including netting a hat-trick in his most recent appearance against the Citizens, in last season's play-off round.

Since the start of the 2019-20 edition (Erling Haaland’s first), only four players have registered 50+ goal involvements in the UEFA Champions League – three of which play for either Real Madrid (Kylian Mbappé 71, Vinícius Júnior 55) or Manchester City (Erling Haaland 61), along with Robert Lewandowski (63).

Among teams still remaining in the 2025-26 edition and prior to the round of 16 ties, the two players who have accounted for the highest share of their side’s goals in the UEFA Champions League this term are Real Madrid’s Kylian Mbappé (54% - 13/24) and Manchester City’s Erling Haaland (47% - 7/15).

Since (and including) the 2022 final against Liverpool, Real Madrid’s Thibaut Courtois has only conceded 39 goals (excl. OGs) from 53.2 xG on target faced in the UEFA Champions League. This positive differential (+14.2) is the highest of any goalkeeper in the competition in this period.