Harsh winter is accelerating Afghanistan’s humanitarian crisis

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We head to Afghanistan as the United Nations calls for urgent action as a million children are on the verge of malnourishment. A world first after a genetically modified pigs heart is transplanted into a man's body in the US, we hear from a doctor on what this means for the future of medicine. We are talking about lockdown parties at Downing street - as the British Prime Minister is under the spotlight again for breaking the rules - Rob Watson with the latest. And we take a closer look at how China is viewing events in Kazakhstan - and what role it will play. Issac will bring us the latest from Cameroon on the Africa Cup of Nations - may not be in the best of moods after Ghana 's loss.