How Memories are Made and Lost

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How are memories made? Claudia Hammond joins an audience at London’s Royal Institution this week to hear from three prize-winning neuroscientists about their cutting-edge research on the brain. Earlier this year Tim Bliss, Graham Collingridge and Richard Morris won the one million Euro Lundbeck Foundation Brain Prize – the world’s biggest prize for neuroscience. They worked out how the brain remembers, how it strengthens connections between different brain cells and why it sometimes forgets. The brain has billions of nerve cells or neurons which are linked by trillions of connections or synapses. It is at these synapses where memories are formed - the memories which make us who we are. The trio’s research was on a mechanism known as Long-Term Potentiation, which works by permanently strengthening the connections between two neurons. It is a bit like beating a path through some long grass – the more you walk the path, the more defined it becomes. Similarly, the more times we have an experience, the stronger the memory gets. Understanding this process brings the exciting possibility of new treatments for conditions like Alzheimer’s disease, schizophrenia and depression. (Photo caption: Healthy brain, 3D magnetic resonance imaging (MRI) scan and wire-frame artwork. Credit: © Zephyr/Science Photo)