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Rosie Yates is now 13 and is starting to display increasingly challenging emotional and physical behaviour, veering wildly from joyous obsessions with the letter X, tigers with Xs on their nose, ticket barriers and Fedex lorries to sudden violent outbursts directed at both her parents and herself.

The family realise that Rosie is simply struggling to cope with the onset of puberty, just like any other teenage girl. Whilst the family deal with a teenage Rosie, their geneticist calls with news of Rosie’s condition.