Roddick was playing his first game since losing the Wimbledon final
Top seed Andy Roddick strolled into round three of the ATP Legg Mason Tennis Classic in Washington DC as several other seeds tumbled out.
Roddick beat Germany's Benjamin Becker 6-3 6-2 but French number three seed Jo-Wilfried Tsonga lost 4-6 7-6 (7-2) 7-6 (7-4) to United States' John Isner.
Seventh seed Tommy Robredo also fell, 6-3 6-2 to Spanish compatriot Juan Carlos Ferrero.
American Mardy Fish, seeded nine, lost 1-6 6-4 6-1 to Philipp Petzschner.
Roddick was making his return following a four-week lay-off after injuring his hip during his epic five-set Wimbledon final defeat by Roger Federer.
"I wanted to work my way into the match, get some rallies going and try to do the basics well," said the world number five.
Roddick sets sights on US Open
"I didn't serve very well, but if there's one thing that's a little rusty that I'm not worried about coming around, it's my serve."
The American will play compatriot Sam Querrey, who beat Igor Kunitsyn of Russia 6-3 6-4, in round three.
Australia's Lleyton Hewitt, who won this title in 2004, saw off Israeli 15th seed Dudi Sela 6-3 2-6 6-2 to set up a third-round meeting with defending champion Juan Martin del Potro.
Other seeds to fall included Serbia's Viktor Troicki who retired with a foot injury when trailing 3-0 to Frenchman Marc Gicquel.
American Wayne Odesnik rallied to overcome 13th seed Igor Andreev of Russia 2-6 7-5 6-4 and French qualifier Sebastien de Chaunac was a 3-6 7-6 (7-3) 7-5 winner against 14th-seeded Russian Dmitry Tursunov.
Fourth seed Fernando Gonzalez of Chile defeated Alejandro Falla of Colombia 7-5 7-5 and Sweden's number five seed Robin Soderling breezed past Russia's Mikhail Youzhny 6-3 6-1.
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