London Irish flanker Declan Danaher will make his 200th Exiles appearance in Saturday's game away to Rovigo.
The 29-year-old will lead the Exiles out in Italy for their final European Challenge Cup pool match.
Coach Toby Booth has made nine changes to the team that thrashed Connacht 75-5 last weekend.
Number eight Richard Thorpe is captain for the first time, with Irish needing a win to secure top seeding for the knock-out stages.
Danaher becomes the fifth London Irish player in the professional era to achieve the double century of appearances for the club.
Coach Toby Booth said: "On behalf of all connected with the club I want to congratulate Declan Danaher on achieving his special milestone.
"As a 'one-club' player he is a rarity in the modern era and is an exemplary professional who has given so much to this club.
"He recently re-signed for another three years and hopefully will enjoy lots more good times over coming seasons."
London Irish: Tomas De Vedia, Adam Thompstone, Elvis Seveali'i, Charlie Gower, James Bailey, Shane Geraghty, Alfredo Lalanne, Tonga Lea'aetoa, James Buckland, Richard Skuse, James Hudson, Gary Johnson, Kieran Roche, Declan Danaher, Richard Thorpe (captain).
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