England swept to their second Six Nations Championship title in three years after a five-try victory. James Haskell, David Wilson, Nick Abendanon (2) and Jordan Crane were the English try scorers, with Toby Flood kicking the remainder of their points.
Ireland's sole points came from a late consolation try from Fionn Carr, who touched down in the left-hand corner.
"This is a great achievement and shows the strength of English rugby coming through," said coach Jim Mallinder.
England U21 Six Nations results:
England 26-18 Wales
Italy 3-48 England
Scotland 22-49 England
France 17 - 30 England
England 40 - 5 Ireland