Wales have handed a surprise first cap to Ospreys number eight Ryan Jones for Saturday's Test against South Africa. The 23-year-old comes in as Michael Owen replaces the suspended Jonathan Thomas in the second row.
Dragons hooker Steve Jones is rewarded for his good form and wins his first cap since facing Japan in 2001.
Scarlets scrum-half Dwayne Peel plays, Gareth Cooper's back injury meaning that Peel's club-mate Michael Phillips makes the bench.
Colin Charvis and Dafydd Jones team-up with Ryan Jones in a beefed-up back row.
Shane Williams takes one of the wing berths, with the other going to Dragons' Hal Luscombe.
Luscombe, who has four caps, was originally left out of the squad because of injury, but is now back to full fitness.
His team-mate Steve Jones gets the go-ahead for his first start over Mefin Davies, who has been playing semi-professional rugby with Neath RFC, and Gareth Williams - who has been out of sorts for the Blues.
Another in-form player, Ospreys' Gavin Henson, will get a chance to impress at inside centre.
Wales coach Mike Ruddock has picked seven Ospreys players in his starting line-up, but none from the Blues, for his first game in charge in Cardiff.
He has named a record six Joneses to face the Tri-Nations champions.
Wales: G Thomas (Toulouse, capt); H Luscombe (Dragons), S Parker (Ospreys), G Henson (Ospreys), S Williams (Ospreys); S Jones (Clermont-Auvergne), D Peel (Scarlets); D Jones (Ospreys), S Jones (Dragons), A Jones (Ospreys), B Cockbain (Ospreys), M Owen (Dragons), D Jones (Scarlets), C Charvis (Newcastle), R Jones (Ospreys).
Replacements: M Davies (Neath), G Jenkins (Blues), L Charteris (Dragons), M Williams (Blues), M Phillips (Scarlets), C Sweeney (Dragons), T Shanklin (Blues).
Referee: Paddy O'Brien (New Zealand)