GUINNESS PREMIERSHIP Venue: Kingsholm Date: Saturday, 29 November Kick-off: 1630 GMT Coverage: Live on BBC local radio & live scores on BBC Sport website
Gloucester's Iain Balshaw will switch from the wing to full-back to cover for Olly Morgan who has a hamstring tweak.
Dave Lewis keeps out Rory Lawson at scrum-half, and Carlos Nieto and Marco Bortolami return to the pack in place of Jack Forster and Alex Brown.
Northampton make three changes to the team that started last week's 28-28 draw with Bath.
Euan Murray, Christian Day and Mark Hopley replace Barry Stewart, Juandre Kruger and Joe Gray.
Gloucester head coach Dean Ryan told BBC Radio Gloucestershire:
"Saints are a good side. They've got some outstanding players and they're a much more collective group than they've been in the past.
"They are capable - with players like Spencer and Reihana - of doing a lot of damage at this level, [so] we've got to be very aware of their threat and at the same time hopefully illustrate the level we can play at."
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