And Emmanuel Adebayor could also miss out as a result of the Football Association disciplinary charges following the game against Arsenal.
The former Arsenal striker faces two charges relating to an alleged stamp on Robin van Persie and his celebrations after scoring City's third in a 4-2 win.
Roque Santa Cruz, a £17m summer signing from Blackburn, will also miss the game, but Bowen said the striker is close to making his debut.
"I doubt he will be available, but it's nice to see him back anyway," he said.
Robinho suffered a stress fracture of the ankle playing for Brazil in the game that also saw Tevez injure his knee.
The Argentine would have been particularly keen to line up against his former side given the circumstances of his departure from Old Trafford.
He became a fans' favourite after joining on loan in August 2007 but left because he was unhappy at the length of time it took United to offer him a permanent deal.
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