Linfield begin their title defence with a home match against Ballymena United.
Manager Jeffrey has been quiet on the transfer front but the Blues are reported to be close to completing the signing of former Crusaders defender David Armstrong, who has returned home from Scottish club Hearts.
Neal Gawley is Glentoran's only major summer signing
Armstrong was in the Linfield team which beat Ballyclare Comrades 4-1 in Tuesday's final pre-season friendly.
Cliftonville will not be in action on the opening day because of their Europa League match against CSKA Sofia on Thursday night.
Glentoran boss Scott Young has not been able to bring in as many new players as he would have liked.
Former Lisburn Distillery forward Neal Gawley is the only new arrival and he could made his competitive debut against his former club as the Glens open the campaign at New Grosvenor on Saturday.
Coleraine, who have added ex-Crusaders defender Aaron Black, Linfield's Johnny Harkness and former Glentoran and Derry winger David Scullion, are at home to Glenavon.
Among the new faces at Glenavon are former Glentoran defender Kyle Neill and Linfield front man Mark Miskimmin.
Newly-promoted Donegal Celtic have a Belfast derby with Crusaders while Newry City start at home to Dungannon Swifts.
Former Cliftonville player and manager Marty Tabb has just taken over at DC and his main objective could be to keep the west Belfast club clear of an immediate return to the Championship.
At Newry, boss Gerry Flynn has added seasoned stars John Convery, Francis Murphy, Conor Downey and Conor Hagan to his panel.
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