Litmanen, who moved from Liverpool to Ajax before last month's transfer deadline, will become his country's leading goalscorer if he finds the back of net on Saturday.
Wales midfielder Robbie Savage has himself promised to give Litmanen a rough ride, and Hughes realises the playmaker will be the one to watch.
"You have to acknowledge a player of Jari Litmanen's standing and ability, and if you don't do that you are liable to be hurt by him," said Hughes.
"But if my players apply themselves as well as they have done recently, we hope to negate the threat he poses."
Hughes will almost certainly stick to his system of playing John Hartson as the lone striker, and packing the midfield with a mixture of exciting dribblers and uncompromising tacklers.
Craig Bellamy eventually joined the squad on Thursday after the Football Association of Wales spent �8,000 on a chartered flight to bring the striker to Finland.
But having only played 30 minutes of competitive football in the past seven months, Bellamy looks destined to start the match on the bench.
Savage, Mark Pembridge and Andy Johnson will probably marshal the midfield, with Ryan Giggs and Simon Davies providing the width.
The only doubt surrounds Cardiff City defender Daniel Gabbidon, who has picked up a foot injury.
Hughes added: "It's important that we get off to a good start. Our last World Cup campaign was always on the back foot because we started off with a defeat.
"It took us a while to get going in that group. For confidence it certainly sets up your campaign if you can get a positive result in your first match.
"I think a draw is a good result here."
Wales: P Jones (Southampton), M Delaney (Villa), A Melville (Fulham), D Gabiddon (Cardiff), G Speed (Newcastle), S Davies (Tottenham), M Pembridge (Everton), R Savage (Birmingham), A Johnson (WBA), R Giggs (Man Utd), J Hartson (Celtic).
HEAD TO HEAD MATCH TOTALS
| All | Finld | Wales | Drawn |
| Total meetings | 7 | 2 | 3 | 2 |
| World Cup Quals | 2 | 1 | 0 | 1 |
| Euro Ch Quals | 4 | 0 | 3 | 1 |
| Friendlies | 1 | 1 | 0 | 0 |
FIXTURE HISTORY
| DATE | | COMP | MATCH | | RESULT |
| 26 May | 1971 | EC Q | Finland | 0-1 | Wales |
| 13 Oct | 1971 | EC Q | Wales | 3-0 | Finland |
| 10 Sep | 1986 | EC Q | Finland | 1-1 | Wales |
| 01 Apr | 1987 | EC Q | Wales | 4-0 | Finland |
| 19 Oct | 1988 | WC Q | Wales | 2-2 | Finland |
| 06 Sep | 1989 | WC Q | Finland | 1-0 | Wales |
| 29 Mar | 2000 | F | Wales | 1-2 | Finland |
WCQ = World Cup
ECQ = European Championship
F = Friendly International
MOST RECENT MEETING
| WALES 1-2 FINLAND |
| Friendly - 29, March, 2000 - Millennium Stadium, Cardiff |
| Wales scorer: Giggs 60 |
| Finland scorer: Litmanen 21, Blake 42 og |
| Wales team: Crossley, Savage (Johnson 79), Barnard (Roberts G 70), Page, Coleman, Melville, Robinson J, Pembridge (Roberts I 86), Blake (Saunders 79), Speed, Giggs. |
| Finland team: Enckleman (Moilanen 46), Reini, Tihinen, Hyypia, Saatamoinen (Tuomela 46), Kolkka, Valakari (Wiss 65), Litmanen (Lehkuoso 70), Forssell (Paatlainen 46), Riihilahti, Nurmela. |
| Referee: Mr Ross - Att: 66,500 |