FA Cup holders Chelsea have been drawn against Manchester City's conquerors Stoke in the quarter-finals.
Championship Reading, who beat West Brom in a replay, will face Aston Villa - who overcame Crystal Palace at the second time of asking.
Portsmouth's reward for their victory against rivals Southampton is a home tie against Birmingham City.
Fulham, who beat Notts County 4-0, will host Tottenham, who overcame Premier League rivals Bolton in a replay.
The quarter-final ties will be played on the weekend of 6 and 7 March.
Draw in full:
Chelsea v Stoke City
Fulham v Tottenham Hotspur
Reading v Aston Villa
Portsmouth v Birmingham City
(Ties to be played on 6 & 7 March).
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