Sevilla, who thrashed Middlesbrough in last season's final, will provide a tough test for Martin Jol's side, with the first leg in Spain on 5 April.

If Spurs go through, they will play Bayer Leverkusen or Osasuna, who knocked out Rangers in the last 16, in the semi-final.

Newcastle's conquerors AZ Alkmaar play Werder Bremen, while Espanyol face Portuguese giants Benfica.

Interview: Sevilla striker Enzo Maresca

606: DEBATE Give your reaction to the draw

Tottenham boss Martin Jol said: "We are in the last eight and it is our fifth quarter-final in three seasons so that is something to be proud of.

"You have got to beat the best to get to the final and there is no such thing as an easy draw at this stage."

Sporting Director Damien Comolli, who was present at the draw in Glasgow, added: "I think it is going to be a fantastic tie involving two very attacking sides with great forwards.

"Sevilla have a super ground with a great atmosphere, while we all know what European nights are like at White Hart Lane so it will be very exciting."

The clash pairs two of the favourites for the competition, with Sevilla pulling off a remarkable escape to go through against Shakhtar Donetsk.

Goalkeeper Andres Palop headed an injury-time equaliser as his side were within seconds of going out of the competition.

It made the score 2-2 on the night, with Sevilla securing a 3-2 win in extra time.

Sevilla are challenging for the title in La Liga, and have former Spurs striker Fredi Kanoute in their ranks.

Quarter-final draw
AZ Alkmaar v Werder Bremen
Bayer Leverkusen v Osasuna
Sevilla vTOTTENHAM
Espanyol v Benfica
(Ties to be played on 5 and 12 April)