First-half goals by Joe Anyinsah and Richard Keogh gave Carlisle their first win in five games as Brighton lost at home yet again.
Anyinsah took advantage of poor defending to net the first just four minutes before Keogh volleyed in from Graham Kavanagh's free-kick.
Brighton winger Seb Carole had a shot against the bar before Nicky Forster put their best chance wide.
He only had the keeper to beat but put the ball wide after it hit a divot.
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Booked: Forster, Virgo.
Carlisle: Williams, Horwood, Murphy, Keogh, Kane, Thirlwell, Anyinsah (Madine 85), Taylor, Neal (Bridges 81), Graham, Kavanagh. Subs Not Used: Howarth, Liddle, Lumsdon.
Booked: Kane, Murphy, Anyinsah, Bridges.
Goals: Anyinsah 24, Keogh 28.
Att: 5,529
Ref: Iain Williamson (Berkshire).
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