Histon player-manager David Livermore was sent off as his side slipped to defeat at Darlington.
Aman Verma cut in from the left and slammed home to give the hosts the lead before Paul Arnison's low shot from the edge of the area doubled the advantage.
Antonio Murray finished Lee Smith's cross to get one back for Histon, only for Livermore to receive his marching orders for a second yellow card.
And the Quakers wrapped it up when Liam Hatch netted from Aaron Brown's cross.
Darlington: Russell, Arnison, Miller, Quinn, Brown, Verma, Gary Smith, Chandler, Taylor (Moore 79), Hatch, Wright (Main 68). Subs Not Used: Burn, Josh Gray, Phil Gray.
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