Grimsby thumped struggling Histon thanks to five second half goals.
Charles Ademeno lashed the visitors in front before doubling the lead with a neat finish just after the interval.
Dean Sinclair fired home from 25 yards and Mark Hudson slotted in from close range before Omer Riza notched with a drive from outside the area.
Lee Peacock quickly re-established the Mariners' four-goal lead with a tap in before Rob Eagle's 35-yard screamer in injury time completed the rout.
Grimsby have now hit 13 goals in their last two outings.
Histon: Welch, Oyebanjo, Livermore (Taaffe 82), Clerima, Zac Mills, Smith, Stevenson (York 82), Wootton, Attwood, Murray, Riza.
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Subs Not Used: Lawton, Dowie, Everdell.
Booked: Oyebanjo, Riza.
Goals: Riza 83.
Grimsby: Arthur, Wood, Atkinson, Kempson, Ridley, Bore, Cummins, Sinclair (Hudson 66), Coulson (Eagle 71), Ademeno, Connell (Peacock 73). Subs Not Used: Croudson, Leary.
Booked: Coulson, Ademeno.
Goals: Ademeno 21, 49, Sinclair 65, Hudson 80, Peacock 84, Eagle 90.
Att: 1,122
Ref: Michael Bull (Essex).
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