Matt Langston snatched a last-minute draw as Eastbourne came from behind three times against 10-man Newport.
Robbie Matthews gave the hosts a third-minute lead but Gary Warren was sent off six minutes later for holding back Jamie Taylor in the box.
Simon Weatherstone converted the penalty, although Newport were back in front soon after through Jamie Collins.
Matt Crabb had Eastbourne level again just after the break but Scott Rodgers made it 3-2 before Langston struck.
Newport County: Garner, Odhiambo, Warren, Todd, John, Collins, Rose, Matthews, Knights (Rogers 57), Reid (Clough 82), Foley (Henry 87).
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Subs Not Used: Proctor, Morgan.
Sent Off: Warren (7).
Goals: Matthews 3, Collins 18, Rogers 80.
Eastbourne Borough: Banks, Austin, Cook (Strevett 85), Langston, Jenkins, Brown (Nathan Crabb 46), Brinkhurst (Baker 90), Matt Crabb, Johnson, Weatherstone, Taylor.
Subs Not Used: Lightwood, Mambo.
Booked: Jenkins, Brinkhurst.
Goals: Weatherstone 9 pen, Matt Crabb 47, Langston 90.
Att: 2,403
Ref: Andrew Davies (Wales).
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