Histon enjoyed a routine win over Southport to pick up their first home points in five games.
Remy Clerima headed his first goal for the Stutes from Daniel Sparkes's corner to give the home side an early lead.
Sparkes was the architect once again as Antonio Murray doubled the advantage by finding the net from 12 yards.
Tony Gray fired home from inside the area to get one back for the Yellows before Earl Davies and Robbie Williams came close, but the home side hung on.
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