Luton Town substitute Ryan Charles grabbed a late winner in a game which saw both sides reduced to 10 men.
Matthew Barnes-Homer slotted Harriers ahead after Dean Courtney picked him out inside the area.
The Hatters then had Rossi Jarvis dismissed for a rash challenge on Chris McPhee before Robbie Matthews was sent off for going in late on Mark Tyler.
Adam Newton equalised with a 20-yard drive and Charles struck a fine volley to secure all three points.
Kidderminster: Coleman, Courtney, McPhee (Caines 45), Riley, Baker, Bennett (Hadley 82), Finnigan, Smikle, Knights (Hayward 54), Matthews, Barnes-Homer.
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Subs Not Used: Dolman, Farrell.
Sent Off: Matthews (45).
Goals: Barnes-Homer 13.
Luton: Tyler, Asafu-Adjaye (Gnakpa 52), White, Pilkington, Murray (Howells 88), Newton, Nicholls, Hall, Jarvis, Craddock, Wright (Charles 61).
Subs Not Used: Gore, Blackett.
Sent Off: Jarvis (41).
Goals: Newton 76, Charles 90.
Att: 2,927
Ref: Richard Wigglesworth (Lancashire).
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