Crawley boosted their play-off hopes by hammering league leaders Burton, who also saw Darren Stride sent off.
Chris Giles headed the home side ahead following a well-worked corner.
Stride was then sent off for bringing down Jamie Cook in the penalty box and Cook picked himself up to slot home the resulting spot-kick.
Mark Byrne missed a golden opportunity for Burton before Danny Forrest fired in a third for Crawley and substitute Lewis Killen headed home the fourth.
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