Nathaniel Knight-Percival scored twice as Histon moved up to third place in the Blue Square Premier table.
Histon dominated the first half, with Jack Midson heading over the top and Alan Marriott denying Antonio Murray.
But Murray put Histon head with a strike into the bottom corner before Josh Simpson crossed for Knight-Percival to nod home.
Marriott denied Knight-Percival after the break but could not prevent him heading his ninth goal of the season.
Histon: Naisbitt, Oyebanjo, Langston, Ada, Gwillim, Barker, Mitchell-King, Simpson (Andrews 88), Knight-Percival, Murray, Midson (Roache 89). Subs Not Used: Welch, Pope, Bygrave.
Booked: Knight-Percival.
Goals: Murray 41, Knight-Percival 45, 86.
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Mansfield:
Marriott, Silk, Garner, Moses, O'Hare, Arnold, D'Laryea, MacKenzie, Williams, O'Connor (Briscoe 54), Duffy (Clare 54). Subs Not Used: White, Woodhouse, Havern.
Att: 914
Ref: Scott Rushton (Lancashire).
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