Craig Nelthorpe scored one and made another as Oxford emerged on top in a fiery encounter which saw each side have a player dismissed.
Nelthorpe's fine 20-yard free-kick put Oxford ahead, then Chris Wilmott headed in Nelthorpe's corner to make it 2-0.
Kettering's comeback hopes were hit as Craig Westcarr was dismissed following an off-the-ball clash with Luke Foster.
But Jean-Paul Marna's low half-volley made it 2-1 before Oxford's Kevin Sandwith saw red for a second booking.
Kettering: Harper, Bennett, Dempster, Geohaghan, Luke Potter, Alfie Potter, Solkhon, Boucaud, Wrack (Seddon 46), Westcarr, Marna (Beardsley 88). Subs Not Used: Whatsize, Richard Graham, Lorougnon.
Sent Off: Westcarr (42).
Booked: Marna, Luke Potter.
Goals: Marna 77.
Oxford Utd: Turley, Batt, Foster, Willmott, Sandwith, Haldane (Hutchinson 82), Chapman, Clist, Nelthorpe (Carruthers 82), Constable, Farrell (Murray 65). Subs Not Used: Hinchliffe, Odubade.
Sent Off: Sandwith (81).
Booked: Sandwith, Willmott, Carruthers.
Goals: Nelthorpe 6, Willmott 8.
Att: 1,716
Ref: Gary Sutton (Lincolnshire).
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