Rushden claimed victory over bottom club Lewes thanks to a second-half penalty from Michael Rankine.
The hosts went ahead after just two minutes when Robert Wolleaston drilled home Marcus Kelly's cross.
But Lewes were level four minutes later when Rhys Henry shot left-footed into the bottom corner.
Rushden regained the lead six minutes after the break when Rankine scored from the spot after Chris Breach had fouled Simon Downer in the box.
Rushden & D'monds: Roberts, Osano, Downer, Hope, Robinson, Beecroft, Wolleaston, Burgess, Kelly, Tomlin, Rankine (Smith 76). Subs Not Used: Jelleyman, Arthur, McGuinness, Hilliard.
Booked: Wolleaston.
Goals: Wolleaston 2, Rankine 51 pen.
Lewes: Banks, Barness, Cullip, Butters, Fisk, Standing, Wilkinson, Keehan, Breach (Cox 70), Henry, Foreman. Subs Not Used: Hall, Saunders.
Booked: Wilkinson.
Goals: Henry 6.
Att: 918
Ref: S Beck (Essex).
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