Lewes came from behind to secure their first win in the Blue Square Premier.
After a disappointing first half, Joe Burnell put the visitors ahead after 61 minutes, heading home substitute Lewis Haldane's inswinging corner.
But Michael Standing levelled for Lewes with a clinical close-range finish 12 minutes from time.
And Sam Gargan completed the turnaround when he slotted in Standing's corner as Lewes climbed off the foot of the Blue Square Premier table.
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Booked: Mayo, Gargan, Standing.
Goals: Standing 79, Gargan 88.
Oxford Utd: Turley, Clarke, Foster, Osborne, Carruthers, Odubade (Hutchinson 89), Murray, Burnell, Trainer (Haldane 53), Constable (Deering 54), Guy. Subs Not Used: Hinchliffe, Quinn.
Booked: Carruthers, Clarke.
Goals: Burnell 63.
Att: 1,156
Ref: I Cooper (England)
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