Ismailia of Egypt scored three goals in six minutes en route to a 6-1 triumph over Enyimba of Nigeria in a Champions League Group A fixture in Cairo on Friday. The result was a rude awakening for Enyimba, who are harbouring dreams of becoming the first team from Nigeria to win Africa's premier club competition.
They also entered Friday's game buoyant after a 3-0 home win over Simba of Tanzania in their first group match.
Their misery was compounded by the dismissal of Ogbonna Okemiri just before half-time.
Atteya Saber converted a late first half penalty for the hosts and Dramane Traore and Mohamed Greisha struck twice each before captain Emad al-Nahas got in on the scoring act with a late effort.
Enyimba snatched a consolation goal two minutes into stoppage time when Obinna Nwaneri found himself unmarked and his shot eluded the outstretched hand of Mohamed Sobhi.
In Friday's other Champions League fixture, Esperance of Tunisia made it two wins out of two when they beat Algeria's USM Alger 1-0 in Group B.
Ivorian striker Amuah Diaky scored the winner three minutes into first half stoppage time - his fourth goal of the competition.
The Algerians were forced to play in Blida, south-west of Algiers, because of a Caf ban on the main stadium in the capital following crowd disturbances last year.
The home side enjoyed plenty of possession and were generally in control against ultra-cautious Esperance.
But after creating several early chances that were foiled by goalkeeper Jean-Jacques Tizie, the Algerians seemed to run out of ideas.