Manchester City 1-1 Stoke City: With international rival Ashley Cole picking up an injury in midweek, Wayne Bridge starts for City and sets about trying to impress watching England boss Fabio Capello
With the prize of a quarter-final place up for grabs, the big-spending hosts take an 11th-minute lead when Shaun Wright-Phillips taps in after an error by Ryan Shawcross
Stoke receive another setback when winger Matthew Etherington slips while trying to tackle Bridge and is taken off with a suspected medial knee ligament injury
He is replaced by Liam Lawrence but he too comes a cropper and has to leave the action as the Potters endure a bruising first half
Despite these problems, it is the visitors who are next to find the net shortly before the hour when substitute Rory Delap powers one of his trademark long throws into the box where Ricardo Fuller heads it in
Striker Roque Santa Cruz is among those who go close to winning the tie but another goal does not materialise as the sides have to settle for a replay
Chelsea 4-1 Cardiff City: The Championship side travel to Stamford Bridge hoping to pull off one of the shocks of the round but find themselves a goal down after only two minutes when Didier Drogba scores
Instead of capitulating, the visitors regroup and find themselves back on level terms in the 34th minute when Michael Chopra heads home from Chris Burke's cross after easily losing his marker Alex
The reigning cup holders recover from this setback and regain the lead early in the second half when Cardiff fail to clear Drogba's pass and Michael Ballack canters through to score
With just over 20 minutes to go, Daniel Sturridge grabs his fourth goal of this FA Cup campaign to make it 3-1 and effectively put the match beyond their opponents
Chelsea make sure of their place in the quarter-finals when a fine header from Salomon Kalou beats goalkeeper David Marshall in the closing minutes
Southampton 1-4 Portsmouth: After a goalless first half, it is the visitors who eventually break the deadlock in the 66th minute when substitute Quincy Owusu-Abeyie curls a lovely effort around goalkeeper Kelvin Davis
Their lead is shortlived, however, as a free-kick finds its way to top scorer Rickie Lambert who guides it home with the back of his head for the League One side
Sadly for the underdogs they fail to build any further momentum and see goals from Aruna Dindane, Nadir Belhadj and Jamie O'Hara (pictured) send their Premier League opponents into the last eight
Derby County 1-2 Birmingham City: With confidence high after a midweek win over Newcastle, the Rams take a 55th-minute lead through Jay McEveley who fires in a shot which goalkeeper Joe Hart fails to deal with
The Premier League side respond well and get an equaliser when Scott Dann heads home from James McFadden's corner with just over 15 minutes to go
The Championship side battle on and look like earning a replay until Liam Ridgewell prods home an injury-time winner after Kevin Phillips's shot comes back off the post
Reading 2-2 West Bromwich Albion: After beating Premier League sides Liverpool and Burnley in the previous two rounds, the Royals entertain the Baggies and have Jimmy Kebe to thank for a goal after only nine seconds
Robert Koren equalises for West Brom ahead of the interval, both sides have a man sent off after the break before Simon Church restores Reading's lead in the 73rd minute
However, Brian McDermott's side are denied a place in the last eight when Joe Mattock pops up with an 87th-minute equaliser to force a replay at The Hawthorns
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