The 31-year-old is making her third appearance in the race, in which she holds a 100% record.
Radcliffe made the fastest debut by a woman over the distance in London in 2002 and set a new world record of two hours, 15 minutes and 25 seconds a year later.
Fans will expect more of the same this time around, especially as the course has been made approximately 45 seconds quicker now the cobbled section around the Tower of London has been removed.
Kenyan world record holder Paul Tergat aims to claim the men's London crown for the first time.
The men's field is, however, packed with quality marathon runners including defending champion Evans Rutto, 2003 winner Gezahegne Abera and Olympic gold medallist Stefano Baldini.
The latest chapter in the world's greatest marathon promises to be just as exciting as anything that has gone before.
| Year | Men | Women |
| 1981 | Dick Beardsley (USA) & Inge Simonsen (Nor) 2:11:48 | Joyce Smith (GB) 2:29:57* |
| 1982 | Hugh Jones (GB) 2:09:24 | Joyce Smith (GB) 2:29:43* |
| 1983 | Mike Gratton (GB) 2:09:43 | Grete Waitz (Nor) 2:25:29* |
| 1984 | Charlie Spedding (GB) 2:09:57 | Ingrid Kristiansen (Nor) 2:24:26 |
| 1985 | Steve Jones (GB) 2:08:16 | Ingrid Kristiansen (Nor) 2:21:06* |
| 1986 | Toshihiko Seko (Jpn) 2:10:02 | Grete Waitz (Nor) 2:24:54* |
| 1987 | Hiromi Taniguchi (Jpn) 2:09:50 | Ingrid Kristiansen (Nor) 2:22:48* |
| 1988 | Henrik Jorgensen (Den) 2:10:20 | Ingrid Kristiansen (Nor) 2:25:41* |
| 1989 | Douglas Wakiihuri (Ken) 2:09:03 | Veronique Marot (GB) 2:26:56* |
| 1990 | Allister Hutton (Gbr) 2:10:10 | Wanda Panfil (Pol) 2:26:31* |
| 1991 | Yakov Tolstikov (Eun) 2:09:17 | Rosa Mota (Por) 2:26:14 |
| 1992 | Antonio Pinto (Por) 2:10:02 | Katrin Dorre (Ger) 2:29:39 |
| 1993 | Eamonn Martin (GB) 2:10:50 | Katrin Dorre (Ger) 2:27:09 |
| 1994 | Dionicio Ceron (Mex) 2:08:53 | Katrin Dorre (Ger) 2:32:34 |
| 1995 | Dionicio Ceron (Mex) 2:08:30 | Malgorzata Sobanska (Pol) 2:27:43 |
| 1996 | Dionicio Ceron (Mex) 2:10:00 | Liz McColgan (GB) 2:27:54 |
| 1997 | Antonio Pinto (Por) 2:07:55 | Joyce Chepchumba (Ken) 2:26:51 |
| 1998 | Abel Anton (Spa) 2:07:57 | Catherina McKiernan (Irl) 2:26:26 |
| 1999 | Abdelkader El Mouaziz (Mor) 2:07:57 | Joyce Chepchumba (Ken) 2:23:22 |
| 2000 | Antonio Pinto (Por) 2:06:36 | Tegla Loroupe (Ken) 2:24:33 |
| 2001 | Abdelkader El Mouaziz (Mor) 2:07:11 | Derartu Tulu (Eth) 2:23:57 |
| 2002 | Khalid Khannouchi (USA) 2:05:38 | Paula Radcliffe (GB) 2:18:56 |
| 2003 | Gezahegne Abera (Eth) 2:07:56 | Paula Radcliffe (GB) 2:15:25 |
| 2004 | Evans Rutto (Ken) 2:06:18 | Margaret Okayo (Ken) 2:22:35 |