Pumas scored seven tries in biggest winning margin and points tally against the Welsh.
Wales scored four tries with scrum-half Tomos Williams and hooker Dewi Lake going over in the first half and flanker Jac Morgan and full-back Blair Murray after the break.
Wales take on Japan in their second autumn Test on Saturday.
Live Reporting
Matt Lloyd
Goodbye from Cardiffpublished at 18:03 GMT 9 November 2025
18:03 GMT 9 November 2025
FT: Wales 28-52 Argentina
Image source, Huw Evans Picture Agency
Well that's it from a thoroughly entertaining opening match of Wales' autumn Test series in Cardiff.
Argentina's early lead through Delgado and Prisciantelli was cancelled out by Lake and Williams for Wales.
But another quickfire double from Benitez Cruz and Mateo Carreras put the visitors back in control at half-time.
Delguy, Delgado, Grondona and a second for man of the match Prisciantelli saw Argentina claim a record win over Wales.
That was despite the return of Louis Rees-Zammit and tries from Murray and Jac Morgan, who suffered a suspected dislocated shoulder in the process of scoring.
If confirmed, that would be a major blow for Wales for their forthcoming games against Japan, New Zealand and South Africa.
But join us next week for the first of those - against the Brave Blossoms - for what will be a crucial game in the world rankings and the subsequent 2027 World Cup pool draw.
An amazing Test for us - Tandypublished at 17:58 GMT 9 November 2025
17:58 GMT 9 November 2025
FT: Wales 28-52 Argentina
Image source, Huw Evans Picture Agency
Wales head coach Steve Tandy said: "We're disappointed with the result but there's some pride in the good things we did and scoring four tries. We could have scored more.
"It was an amazing test for us. We can't die wondering and the only way to gain experience is by being out there. Dan Edwards, on his third of fourth cap, some of the moments he had in the game were great. And the only way to get that is by doing it.
"You're coming up against a really battle-hardened Argentina team who have possibly 800-900 caps in their squad and have just played South Africa and New Zealand.
"They were outstanding in the air and the tries either side of half-time was a blow.
"There is always that disappointment when you concede seven tries and there were too many sloppy moments to win any big game.
"That's not something we want defensively, but also we know the bits where we need to grow.
"But it's also about the importance of what we're trying to be, making sure that we reflect on what we set out to do and there are a lot of things that we can tidy up pretty quickly."
Tough fixtures on the horizonpublished at 17:51 GMT 9 November 2025
17:51 GMT 9 November 2025
FT: Wales 28-52 Argentina
Gwyn Jones Former Wales captain on S4C
There is so much optimism around Steve Tandy and his side after two years of suffering. In those two years, there wasn't really any attacking or creative rugby.
Today, we saw aspects of the team improving but it just shows that it's a long term project, there is a lot of coaching to do.
Next week's game is important because New Zealand and South Africa are to come, then starting the Six Nations against England and France.
That's the magnitude of the task but everyone is behind them wanting them to succeed.
We saw improvementspublished at 17:41 GMT 9 November 2025
17:41 GMT 9 November 2025
FT: Wales 28-52 Argentina
Ian Gough Former Wales international on BBC Radio Wales
You've got to take some positives from the game especially after being shell-shocked in the first ten minutes.
We got back into it but the two yellow cards disrupted us as well.
Second half, we're playing against a team six places higher than us and they proved that in the way they were very clinical in parts.
But there are so many positives for us - the inventiveness in the way we upped the tempo when we had to. We surprised them and we were quite clinical in their half. We wanted to see improvements and we did in places.
Unfortunately international rugby is a relentless arena. You get little things wrong and its exacerbated hugely and that happened as well.
Inconsistency costs Walespublished at 17:30 GMT 9 November 2025
17:30 GMT 9 November 2025
FT: Wales 28-52 Argentina
Ken Owens Former Wales hooker on S4C
The amount of missed tackles is what stands out. Wales have conceded 52 points.
To be fair, there were aspects of the game where there were positives and you could start to see glimpses of the shape that they want to play. There just wasn't enough consistency over the course of the 80 minutes.
It's early days and positives were there to build on. There just needs to be a spark next week to get a win and get some confidence.
You can still see there's a lack of confidence in this squad.
We've got to learn quickly - Beardpublished at 17:28 GMT 9 November 2025
17:28 GMT 9 November 2025
Image source, Huw Evans Picture Agency
Wales lock Adam Beard told S4C: "Even though it doesn't look it on the scoreboard, there are still lots of positives - some quality D (defence) sets, some of our attacking shapes were awesome.
"That's what we want to do, we want a crowd excited, we want to get them off their feet, we want the fans to be proud of what we're putting out on the pitch.
"Get those lapses in concentration right and the ill-discipline and we're going to be in a better place spot, but we've got to learn quickly and we've got to do it next week against Japan."
No quick fixpublished at 17:25 GMT 9 November 2025
17:25 GMT 9 November 2025
FT: Wales 28-52 Argentina
Richie Rees Former Wales international on BBC Radio Wales
Wales were good in the first half. They brought themselves back into the game at 14-14 but we struggled in second half with the physicality of the game.
When you lose someone like Jac Morgan, such a talisman for Wales as a group it's a real blow. And we picked up another few injuries as well.
Argentina have played some world class rugby over the last few months.
Wales are also a new group coming together and it will take time. People have got to be invested for the long term.
There's a good core group of players, but we've got to understand where we are in the pecking order at the moment. There is no quick fix and it will take time.
A 50/50 performance - Lakepublished at 17:22 GMT 9 November 2025
17:22 GMT 9 November 2025
FT: Wales 28-52 Argentina
Image source, Huw Evans Picture Agency
Wales hooker Dewi Lake told S4C: "We showed glimpses of what this new story is going to bring us.
"There were a few times in attack that we looked great with the ball but there were a few lapses in concentration.
"Against a team like Argentina, they are going to punish you. It's hard to assess because it didn't feel too bad out on the field but to look up at the scoreboard and see 50 points for the opposition, something has clearly gone wrong.
"Things have changed for us over the last two weeks. We have had to learn a lot but that isn't an excuse for conceding 50 points.
"We have seen glimpses of the patterns we can play and a few nice defensive sets but we have to keep working on them."
Man of the Match: Geronimo Prisciantelli (Argentina)published at 17:17 GMT 9 November 2025
17:17 GMT 9 November 2025
FT: Wales 28-52 Argentina
Image source, Huw Evans Picture Agency
Seems like we were a little premature dishing out the man of the match award earlier.
Yes it was a Puma but the award has gone to fly-half Geronimo Prisciantelli.
He scored two tries and created two more.
He finished off a scorching break in the first half and then picking Ben Thomas' pocket with an interception for the second, while his passing and kicking set up another brace.
He said: "We're really happy with the result. We knew Cardiff is a very difficult place to come and we knew Wales would be tough so we wanted to stick to the plan."
Wales sweat on Morgan injurypublished at 17:10 GMT 9 November 2025
17:10 GMT 9 November 2025
FT: Wales 28-52 Argentina
Image source, Huw Evans Picture Agency
Wales are waiting to discover the extent of a seemingly significant injury to captain Jac Morgan.
The Ospreys open-side flanker was taken off after appearing to seriously damage his arm in the act of scoring a second-half try.
Morgan's eighth international try was the highlight of a typically impressive all-round individual display in defence and attack.
It would be a major blow for Wales to lose their 25-year-old skipper, who could be in danger of missing the remaining three Tests of their autumn series.
Aaron Wainwright also limped off with what looked a heavy blow to his leg so Steve Tandy could be worrying about the shape of his back-row next week.
Japan come to Cardiff next Saturday, before New Zealand and South Africa visit over the following two weekends.