Coordination and control - the human endocrine system - AQA Role of glucagon in blood sugar levels – Higher

The endocrine system secretes hormones into the bloodstream from glands throughout the body. Hormones produce an effect on specific target organs in the body.

Part ofCombined ScienceHomeostasis and response

Role of glucagon in control of blood sugar levels – Higher

Negative feedback

In blood glucose regulation, the hormone insulin plays a key role. When blood sugar rises in the blood, insulin sends a signal to the liver, muscles and other cells to store the excess glucose. Some is stored as body fat and other is stored as glycogen in the liver and muscles. Whereas, if the blood glucose level is too low, the liver receives a message to release some of that stored glucose into the blood. This change is brought about by another hormone produced by the pancreas called glucagon.

This is an example of negative feedback.

A flowchart to demonstrate negative feedback

Action of insulin

Low glucoseHigh glucose
Effect on pancreasInsulin not secreted into the bloodInsulin secreted into the blood
Effect on liverDoes not convert glucose into glycogenConverts glucose into glycogen
Effect on blood glucose levelIncreasesDecreases
Effect on pancreas
Low glucoseInsulin not secreted into the blood
High glucoseInsulin secreted into the blood
Effect on liver
Low glucoseDoes not convert glucose into glycogen
High glucoseConverts glucose into glycogen
Effect on blood glucose level
Low glucoseIncreases
High glucoseDecreases