Johnny Depp's second Pirates film was nominated for four awards

The second Pirates film won best movie, with Depp, who played Captain Jack Sparrow, picking up best performance.

Accepting the award on stage with producer Jerry Bruckheimer, Depp said: "I'd like to thank this man and Disney for not firing me."

Meanwhile, the third film, At World's End, has topped the North American box office chart for the second week.

The new movie, which also stars Keira Knightley and Orlando Bloom, took $43.2m (�21.8m) over the weekend, taking its total bounty to $216.5m (�109m).

Will Ferrell and Sacha Baron Cohen recreated their award-winning kiss

At the MTV ceremony, British actor Sacha Baron Cohen, who wrote and starred in Borat: Cultural Learnings of America for Make Benefit Glorious Nation of Kazakhstan, won best comedic performance.

Speaking on stage, he said: "Unfortunately Borat can't be here tonight, he's been feeling the pressures of fame and had to check himself into rehab."

Cohen also won best kiss along with Will Ferrell for their embrace in Talladega Nights: The Ballad of Ricky Bobby.

The two comedians shared a long and passionate smooch on stage, which ended up with them rolling around on the floor as they accepted their awards.

Actress Cameron Diaz presented Mike Myers with his award

Other big winners included Mike Myers, who won the MTV generation award, while Jack Nicholson took the prize for best villain for his mobster role in The Departed.

The prize for best fight went to Gerard Butler, who battled "The Uber Immortal" in the epic 300.

Will Smith's nine-year-old son Jaden won the breakthrough performance prize for his role in The Pursuit of Happyness.

The ceremony, which was hosted by comedienne Sarah Silverman, took place at the Gibson Amphitheater.