Sixth seed Andy Roddick is out early on Court Lenglen against Russian qualifier Teimuraz Gabashvili and the American finds the going tough, losing the first set 6-4
Roddick fails to recover and is broken three more times by his 25-year-old opponent as he becomes the most high-profile casualty in the men's draw so far, losing 6-4 6-4 6-2
Over on Philippe Chatrier, top seed Serena Williams loses her first service game against Anastasia Pavlyuchenkova but the American breaks back and does not lose another game in the first set
Any thoughts of a quick victory are shattered though when Pavlyuchenkova breaks twice in the second set and an unwell Williams is forced to call on the doctor and trainer
The treatment works for Williams though and she regains her composure to reach the last 16 with a topsy-turvy 6-1 1-6 6-2 victory
Russia's Nadia Petrova is next up on Chatrier and takes just 14 minutes to complete a 6-7 6-4 10-8 victory over Aravane Rezai after they resumed at 7-7 in the deciding set
Any hopes of a home winner in the women's draw are ended when France's Marion Bartoli is beaten 7-6 (9-7) 6-2 by Israel's Shahar Peer, who will face Serena Williams in the last 16
Number three seed Novak Djokovic has few problems in the first set of his third-round match against Romania's Victor Hanescu but the number 31 seed takes the second set to level
But the Serb grinds his way to a 6-3 3-6 6-3 6-2 win and will face either Juan Carlos Ferrero or Robby Ginepri in the next round
Jurgen Melzer pulls off a shock as he dispatches ninth seed David Ferrer in straight sets. The Austrian will play Teimuraz Gabashvili for a place in the quarter-finals.
Three of Lleyton Hewitt's last four French Open campaigns have been ended by Nadal, but the Australian got onto the front foot early by breaking in his opponent's opening service game
But the strain starts to show on Hewitt as the Spaniard takes the opening set 6-3 and finds an ominous rhythm
The end of the match comes with a 6-3 6-4 6-3 win for Nadal and a sweaty momento for a fan
All eyes will be on USA's Robby Ginepri as he attempts to follow up a surprise win over former world number one Juan Carlos Ferrero with another shock when he takes on Novak Djokovic in the last 16
A typically vocal display by Maria Sharapova is brought to a premature end for the day as bad light sees her match against Justine Henin suspended at one set apiece
But Jelena Jankovic does manage to stay on court long enough to see off Alona Bondarenko 6-4 7-6 in the gathering gloom
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