Former Wimbledon champion Goran Ivanisevic suffered a 6-3 6-2 first round defeat at the hands of seventh seed Sjeng Schalken in Rotterdam. Ivanisevic made constant errors and was only briefly spared by trademark aces.
Schalken broke him in the first set and twice more in the second to complete his victory in 53 minutes.
Since returning from a seven-month break following surgery, Ivanisevic, 32, beat Bohdan Ulihrach in Milan last week but lost in the second round.
"The most important thing now is to stay healthy and enjoy it," said Ivanisevic.
"My serve will never be at the level it was before. I still have some pain, but I can also still hit aces.
"I had something like 47 in two matches last week, that's fine. The serve is still there, it's just the little things after the serve.
Putting it together in practise and then in a match is a completely different story."
Third seed Rainer Schuettler finally claimed his first win of the year, beating Austrian Stefan Koubek 6-3 6-2.
The German had lost in the first round in Doha, Sydney and at the Australian Open last month.
Radek Stepanek defeated Olivier Rochus 5-7 6-2 6-2, while fourth seed Karol Kucera crashed out 6-2 7-6 to John van Lottum.